Botulinum neurotoxin type-A for primary stabbing headache: an open study

Botulinum neurotoxin type-A for primary stabbing headache: an open study.

Primary stabbing headache is an ultra-short headache, associated with primary headaches, more prevalent in women and with a poor response to therapy. The effect of botulinum neurotoxin type-A (BoNTA) on primary stabbing headache was investigated in 24 patients. Three patients showed complete remission. Nineteen patients showed a decrease in their primary stabbing headaches that started in the s...

Neurologic uses of botulinum neurotoxin type A

This article reviews the current and most neurologic uses of botulinum neurotoxin type A (BoNT-A), beginning with relevant historical data, neurochemical mechanism at the neuromuscular junction. Current commercial preparations of BoNT-A are reviewed, as are immunologic issues relating to secondary failure of BoNT-A therapy. Clinical uses are summarized with an emphasis on controlled clinical tr...

Botulinum Neurotoxin Type A in Neurology: Update

This paper reviews the current and most neurological (central nervous system, CNS) uses of the botulinum neurotoxin type A. The effect of these toxins at neuromuscular junction lends themselves to neurological diseases of muscle overactivity, particularly abnormalities of muscle control. There are seven serotypes of the toxin, each with a specific activity at the molecular level. Currently, ser...

Purification of Clostridium botulinum type A neurotoxin.

Stabbing headache in a teenager.

CLINICAL HISTORY A 17-year-old adolescent girl was seen with a 4-year history of head pain which, initially, was occasional. After gradually increasing in frequency during the last year, this pain has been occurring daily. She describes a stabbing pain in the left or right temple lasting seconds. She often has multiple recurring pains (pain for seconds, brief remission, recurrent pain, etc) wit...